CHEMOPREVENTIVE EFFECT OF ACETOHEXAMIDE AND STIGMASTEROL AGAINST UVB- INDUCED SKIN CANCER

Abstract

Acetohexamide (Dymelor) is an Oral Hypoglycemic agent, which was shown to reduce the UV induced DNA damage in Xeroderma pigmentosum patients. But the studies on Acetohexamide has not been thoroughly investigated for UV B irradiation induced carcinogenesis in mice. Stigmasterol is one of the plant-derived sterols which is known to possess various antitumor and anticancer properties. The objective of this study is to comparatively evaluate the chemopreventive effect of Acetohexamide and Stigmasterol in Skin Cancer-induced by UV-B irradiation in Swiss Albino Mice. The chemopreventive role of Acetohexamide and Stigmasterol induced skin papillomagenesis was evaluated in UV-B irradiation induced mice using the parameters like tumor incidence, tumor burden, tumor weight, tumor volume, and the excised skin was subjected to histopathological studies. The results from the histopathological findings are in support of the antitumor activity of Acetohexamide and Stigmasterol. Moreover, the study reveals that the mechanism of the Chemopreventive action against UV B induced skin cancer may be due to the Antioxidant properties of the compounds.