FORMULATION AND EVALUATION OF METFORMIN TRANSDERMAL PATCHES: FORMULATION AND EVALUATION OF METFORMIN TRANSDERMAL PATCHES

G. Srilaxmi; V. Uma maheshwar rao

Authors

G. Srilaxmi TRR college of pharmacy, Meerpet, Saroornagar (M), Rangareddy (D), Hyderabad, Telangana, India
V. Uma maheshwar rao TRR college of pharmacy, Meerpet, Saroornagar (M), Rangareddy (D), Hyderabad, Telangana, India

Keywords:

Metformin, HPMC, Ethylcellulose, Sodium Alginate, Solvent casting technique, Drug release studies

Abstract

The objective of present study was to develop matrix type transdermal therapeutic systems of Metformin using various hydrophilic and hydrophobic polymers as matrix formers.

Results revealed that prepared patches showed good physical characteristics, no drug-polymer interaction and no skin irritation was observed. The in vitro release study revealed that F4 formulation showed maximum release in 12 hrs. Formulation F4 was subjected for accelerated stability studies. The F4 formulation was found to be stable as there was no drastic change in the Physico-chemical properties of the patches, which was also confirmed by FTIR. Thus conclusion can be made that stable transdermal patches of Metformin has been developed. F1, F2, F3, F4 formulations showed highest cumulative percentage drug release of 92.63%, 89.35%, 88.98%, 96.28% were obtained during in vitro drug release studies after 12 hrs. The release of Metformin appears to be dependent on lipophilicity of the matrix.

Moderately lipophillic matrices showed best release. The predominant release mechanism of drug through the fabricated matrices was believed to be by diffusion mechanism. Based upon the in vitro dissolution data the F4 formulation was concluded as optimized formulation.

Views