FORMULATION AND EVALUATION OF ATENOLOL TRANSDERMAL PATCHES

Abstract

The objective of present study was to develop matrix type transdermal therapeutic systems of Atenolol using various polymers such as Sodium alginate, HPMC, Ethylcellulose and Eudragit polymers as matrix formers. Results revealed that prepared patches showed good physical characteristics, no drug-polymer interactions. The in-vitro release study revealed that F-1 formulation showed maximum release in 8 hrs. Formulation F-1 was subjected for accelerated stability studies. The F1 formulation was found to be stable as there was no drastic change in the Physico-chemical properties of the patches, which was also confirmed by FT-IR Spectroscopy. Thus conclusion can be made that stable transdermal patches of Atenolol has been developed. F1 formulation showed highest cumulative percentage drug release of 96.63 % which was obtained during in-vitro drug release studies after 8 hrs.

 The release of Atenolol appears to be dependent on lipophilicity of the matrix. Moderately lipophillic matrices showed best release. The predominant release mechanism of drug through the fabricated matrices was believed to be by diffusion mechanism. In the present study based upon the in-vitro dissolution data the F-1 formulation was concluded to be an optimized formulation.