Design Prepare and characterization of Pregabalin loaded solid lipid Nanoparticles

Abstract

Targeted drug delivery systems are one of the most challenging study topics in the pharmaceutical sciences. New obstacles have emerged in the quest to perfect medication delivery as a result of the development of colloidal delivery methods such as liposomes, micelles, and nanoparticles. In order to increase the bioavailability of pregabalin, this research aimed to quantify the impact of lipids during the manufacture of pregabalin-loaded SLN. The FT-IR study showed that the chosen lipid, medication, surfactant, and combination had no negative interactions with one another. Using lipid GMS and surfactants Tween80, Polaxamer 188, and Span20, SLNs were produced through heat homogenization followed by ultrasonication. It was found that the best formulation would have the desired drug release profile if the dispersity index, nanoparticle size, zeta potential, and entrapment efficiency were all consistent across the board. Thepoloxamer188 had significant influence onthedrugreleaseofPregabalin. Therefore, SLNs are a potentially useful delivery strategy for improving the bioavailability of the poorly soluble medication Pregabalin.