EXTENDED RELEASE TABLETS OF LAMIVUDINE: FORMULATION AND IN VITRO EVALUATION

Abstract

The main objective of the present work is to formulate and evaluate extended release

tablets of Lamivudine using different polymers viz. Hydroxyl Propylmethyl Cellulose, Eudragit

RPLO, Polyethoxyoxides, Poly Vinyl pyrrolidine K30 (PVP K30), Sodium Carboxymethyl

Cellulose, Microcrystalline Cellulose (MCC). Then the release rates were get retarded by

increasing the polymer concentrations from lower to higher and it shows release of drug

from polymer for extended periods of time. In this study, the extended relase tablets are

prepared by direct compression technique by using the various polymers in increasing

concentration. The pre-compression and post-compression studies are performed like Bulk

density, Tapped density, Angle of repose, Cars index, Hauser’s ratio. The post-compression

evaluation studies like thickness, weight variation, hardness, friability, uniformity of drug

content, dissolution. After evaluation of physical properties of tablet, the in-vitro drug

release study of extended release tablet of Lamivudine was performed in 0.1N HCl for 2

hours and in phosphate buffer pH 7.4 up to 24 hours. The formulation F4 and F9 shows

maximum drug release with in 24 h due increasing the concentration of HPMC K15 M and the

Eudragit RPLO. Eudragit RPLO and HPMC K 15M shows maximum cumulative drug release of

99.78% and 99.99%. Then both formulations taken as optimum formulations and conducted

stability studies to these two formulations for 3 months. Then again evaluated the pre-

compression and post-compression stability. Results obtained from the stability studies

cannot observe any changes after conducting the stability studies.